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Vino Nobile di Montepulciano is indeed differentiated from Montepulciano di Abruzzo primarily by its grape composition. Vino Nobile di Montepulciano must contain at least 70% Sangiovese, locally known as Prugnolo Gentile. This is significant because it establishes the wine's identity and quality, showcasing the characteristics of the Sangiovese grape—its bright acidity, fruity flavors, and aging potential.

Montepulciano di Abruzzo, on the other hand, can be primarily made from the Montepulciano grape and does not have the same premium classification requirements. This key difference in the mandatory grape content emphasizes the quality and style distinctions between these two Italian wines, with Vino Nobile di Montepulciano often being regarded as a more prestigious wine due to its higher Sangiovese percentage and the specific regulations governing its production.